AKHTAR, NADIM,BRADBURY, ROBERT HUGH,BUTTAR, DAVID,CURRIE, GORDON STUART,DE SAVI, CHRISTOPHER,YAVARI, NEDA,NORMAN, RICHARD ALBERT,OSBORNE, MATTHEW,RABOW, ALFRED ARTHUR,REDFEARN, HEATHER MARIE,WILLIAMS,
申请号：
PE2015002429
公开号：
PE20160874A1
申请日:
2014.05.27
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
REFERS TO COMPOUNDS OF FORMULA (I) OR THEIR SALTS WHERE R1, R2, R3, R4 AND R5 ARE AS DEFINED IN THE DESCRIPTION. THEY ARE PREFERRED COMPOUNDS: ACID (E) -3- (3,5-DIFLUORO-4 - ((1R, 3R) -2- (2-FLUORO-2-METHYLPROPIL) -3-METHYL-2,3,4,9 -TETRAHYDRO-1H-PIRIDO [3,4-b] INDOL-1-IL) FENIL) ACRILICO； ACID (E) -3- (4 - ((1R, 3R) -2- (2-FLUORO-2-METHYLPROPIL) -3-METHYL-2,3,4,9-TETRAHYDRO-1H-PIRIDO [3,4 -b] INDOL-1-IL) PHENYL) ACRYLIC； AMONG OTHERS. IT ALSO REFERS TO A PROCESS FOR ITS PREPARATION AND A PHARMACEUTICAL COMPOSITION. THESE COMPOUNDS REDUCE THE EXPRESSION OF THE STROGENIC RECEPTOR (ER1 OR ER ALPHA) IN A SELECTIVE WAY (SERD) BEING USEFUL FOR THE TREATMENT OF CANCERSE REFIERE A COMPUESTOS DE FORMULA (I) O A SUS SALES DONDE R1, R2, R3, R4 Y R5 SON TAL COMO SE DEFINEN EN LA DESCRIPCION. SON COMPUESTOS PREFERIDOS: ACIDO (E)-3-(3,5-DIFLUORO-4-((1R,3R)-2-(2-FLUORO-2-METILPROPIL)-3-METIL-2,3,4,9-TETRAHIDRO-1H-PIRIDO[3,4-b]INDOL-1-IL)FENIL)ACRILICO； ACIDO (E)-3-(4-((1R,3R)-2-(2-FLUORO-2-METILPROPIL)-3-METIL-2,3,4,9-TETRAHIDRO-1H-PIRIDO[3,4-b]INDOL-1-IL)FENIL)ACRILICO； ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCESO PARA SU PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS REDUCEN LA EXPRESION DEL RECEPTOR ESTROGENICO (ER1 O ER ALFA) DE FORMA SELECTIVA (SERD) SIENDO UTILES PARA EL TRATAMIENTO DEL CANCER
