Xuqing Zhang,Marta C Abad,Alan C. Gibbs,Gee-Hong Kuo,Fengbin Song,Zhihua Sui,Lawrence C. Kuo
申请号：
US14338816
公开号：
US09771375B2
申请日:
2014.07.23
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention is directed to substituted indazole compounds, pharmaceutical compositions of these compounds and methods of use thereof. The compounds of the present invention are ketohexokinase (KHK) inhibitors, useful for treating or ameliorating a KHK mediated metabolic disorders and/or diseases such as obesity, Type II diabetes mellitus and Metabolic Syndrome X. In some embodiments, the substituted indazole compounds are of formula I, wherein R1-R3, Q, X, Y, Z, a, and b are defined herein.
