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INHIBITEUR D'URAT1
专利权人:
J-Pharma Co., Ltd.; Ltd.;Nippon Chemiphar Co.;Dethree Res. Lab. Inc.;Nippon Chemiphar Co., Ltd.
发明人:
ENDO, Tsuyoshi,KOBAYASHI, Kunio,TANAKA, Hiroto,SAITO, Daisuke,HIRANO Masuharu,ENDOU, Hitoshi,ANZAI, Naohiko
申请号:
EP15875408
公开号:
EP3241822A4
申请日:
2015.12.28
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
Provided are a compound represented by the following Formula (III), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt or solvate thereof used as a therapeutic agent for gout or hyperuricemia. (In the Formula (III), R 1a , R 2a , R 6a , and R 7a represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, or a cyano group, R 3a and R 8a form a benzene ring or a 5-membered heteroaryl ring containing 1 to 3 heteroatoms, as a ring constituent element, selected from nitrogen atoms, oxygen atoms, and sulfur atoms together with two carbon atoms to which R 3a and R 8a are bonded, R 4a and R 5a form a benzene ring together with two carbon atoms to which R 4a and R 5a are bonded or represent any of the groups represented by R 1a described above, W a represents CR 10a or N, and where, R 10a represents any of the groups represented by R 1a , X a represents an oxygen atom or a sulfur atom, Y a represents an alkylene chain having 1 to 8 carbon atoms, and where, the alkylene chain may be substituted with an alkyl group having 1 to 8 carbon atoms and the alkylene chain may be a linear or branched alkylene chain, the branched alkylene chain may have a 3- to 7-membered ring formed by side chains bonded to carbon atoms which are the same as or different from each other, together with the carbon atoms to which the side chains are bonded and may have a double bond in the middle thereof, and Z a represents CO 2 H.
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