A compound of the formula I Where (a) Z is>； = CR2； (b) R0 is hydrogen； halogen, C1-C4 unsubstituted alkyl, C1-4 unsubstituted alkoxy； (c) R1 is hydrogen； halogen, C1-C8 alkyl, C1-8 substituted alkyl； -SO2N (R10) R11； -N (C1-4 alkyl) C (O) C1-4 alkyl； a 5- or 6-membered heterocyclic ring optionally substituted on an N atom of the ring； C1-C8 alkoxy； phenyl； or R1 forms together with R2 and the C atoms to which R1 and R2 are attached, a 5-10 membered aryl or heteroaryl, the latter comprising 1 or 2 nitrogen atoms； or R1 and R2 together with the C atoms to which they are attached, a non-aromatic carbocyclic residue of 5 to 15 members； or R1 and R2 together with the C atoms to which they are attached, a 5 to 15 membered non-aromatic heterocyclic residue comprising 1 to 5 O atoms as heteroatoms； whose heterocyclic residue can be optionally substituted； (d) R2 is hydrogen； hydroxy； C1-C8 alkyl； C1-8 substituted alkyl； C1-8 alkoxy； C1-C4 alkoxy C1-C8 alkoxy； -CON (R10) R11； -SO2N (R10) R11； fluoro-C1-5 alkoxy comprising 2 to 5 fluorine atoms； C1-C8 C1-C8 alkoxy C1-C8 alkoxy； C2-C8 alkenyloxy； halo-C2-C8 alkenyloxy； benzyloxy； or -N (CH3) (R13), wherein R13 is methyl or benzyl； (e) R3 is SO2NR10R11； (f) R4 is hydrogen； or together with R3 and the N and C atoms to which R3 and R4 are attached a 6-membered heterocyclic ring； (g) R5 is hydrogen； halogen； C1-4 alkyl； or CF3； (h) R6 is hydrogen； (i) one of R10 and R11, independently, is hydrogen or C1-4 alkyl and the other is hydrogen； C1-8-alkyl； C1-8 substituted alkyl； a heterocyclic ring； C2-8 alkenyl； C3-8 cycloalkyl； C1-8 C1-4 alkoxy alkyl； or C1-8 hydroxy C1-8 alkoxy alkyl； (i) R7 is tetrahydropyran-2-ylmethoxy, tetrahydrofuran-2-ylmethoxy, thiazol-2-ylmethoxy, 2- (2-oxo-pyrrolidin-1-yl) -ethoxy, 3-pyridylmethoxy or phenyl, and R8 and R9 are each hydrogen； or (ii) R7 is 2-hydroxy-ethylamino and R8 is hydroxymethyl and R9 is hydrogen； or (iii) R7 is piperazin-1-yl, 4-isopropyl-piperazin-1-yl, 4- (2-methoxyethyl) -piperaz
