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New derivatives of peptides as antibiotics
专利权人:
Nosopharm;Institut National De La Recherche Agronomique
发明人:
GUALTIERI, Maxime,VILLAIN-GUILLOT, Philippe,GIVAUDAN, Alain,PAGES, Sylvie
申请号:
ES12778971
公开号:
ES2657930T3
申请日:
2012.09.28
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Compound of formula (I): Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-NH- (CH2) nR (I) in which Xaa1, Xaa2, Xaa3, Xaa8 and Xaa10 are selected independently of the group consisting of lysine, 3-hydroxylysine, 4-hydroxylysine, 5-hydroxylysine, 3,4-dihydroxylysine, 3,5-dihydroxylysine, 4,5-dihydroxylysine, ornithine, 3-hydroxyiornithine, 4-hydroxyiornithine, 3,4-dihydroxyiornithine, 2,4-diaminobutanoic acid, 3-hydroxy-2,4-diaminobutanoic acid, arginine, histidine, serine, and threonine; Xaa4 is glycine; Xaa5 is ornithine Xaa6 is proline, 3-hydroxyproline, 4-hydroxyproline, aziridin-2-carboxylic acid, azetidin-2-carboxylic acid, pipecolic acid, 4-oxaproline, 3-thiaproline, 4-thiaproline, 3,4-dehydroproline, 4-aminoproline, 4-fluoroproline, α-methylproline, or α-allylproline; Xaa7 is histidine Xaa9 is arginine, 2,3-dehydroarginine, citrulline, 2,3-dehydrocitrulline, canavanine, or 2,3-dehydrocanavanine; n is 2, 3, 4, 5, 6, 7, 8, 9, or 10; and R is -OH, -NH2 or -COOH.Compuesto de fórmula (I): Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-NH-(CH2)n-R (I) en el que Xaa1, Xaa2, Xaa3, Xaa8 y Xaa10 se seleccionan independientemente de entre el grupo que consiste en lisina, 3-hidroxilisina, 4-hidroxilisina, 5-hidroxilisina, 3,4-dihidroxilisina, 3,5-dihidroxilisina, 4,5-dihidroxilisina, ornitina, 3-hidroxiornitina, 4-hidroxiornitina, 3,4-dihidroxiornitina, ácido 2,4-diaminobutanoico, ácido 3-hidroxi-2,4- diaminobutanoico, arginina, histidina, serina y treonina; Xaa4 es glicina; Xaa5 es ornitina Xaa6 es prolina, 3-hidroxiprolina, 4-hidroxiprolina, ácido aziridin-2-carboxílico, ácido azetidin-2-carboxílico, ácido pipecólico, 4-oxaprolina, 3-tiaprolina, 4-tiaprolina, 3,4-deshidroprolina, 4-aminoprolina, 4-fluoroprolina, α-metilprolina o α-alilprolina; Xaa7 es histidina Xaa9 es arginina, 2,3-deshidroarginina, citrulina, 2,3-deshidrocitrulina, canavanina o 2,3-deshidrocanavanina; n es 2, 3, 4, 5, 6, 7, 8, 9 o 10; y R es -OH, -NH2 o -COOH.
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