Takashi ABIKO,Kazuhisa UCHIYAMA,Tomoko MOTOHASHI,Tomoko MATSUDA,Miharu SUDA
申请号：
US13740026
公开号：
US20130184308A1
申请日:
2013.01.11
申请国别(地区):
US
年份:
2013
代理人:
摘要：
An object of the present invention is to provide an activated blood coagulation factor X (FXa) inhibitor that reduces the risk of bleeding caused by the treatment of thromboembolism. The present invention provides an oral anticoagulant agent comprising a compound represented by the following formula (1):or a pharmacologically acceptable salt thereof, or a hydrate thereof, as an active ingredient, wherein (A) a factor involved in the risk of bleeding caused by the anticoagulant agent is selected as a dose determinant； (B) a reference value of the dose determinant is set； (C) the dose determinant of a patient in need of administration is measured； and (D) the dose of the anticoagulant agent is selected with the reference value as an index.
