The present invention relates to a Croton macrostachyus herbal acupuncture extract showing a pain killing effect by active ingredients of plants belonging to Euphorbiaceae. The purpose of the present invention is to solve side effects of existing painkillers. By comprising active ingredients of plants belonging to Euphorbiaceae, the extract of the present invention shows excellent pain killing effects without side effects.COPYRIGHT KIPO 2017(1) 기술분야대극과(Euphorbiaceae, 大戟科)에 속하는 식물의 유효성분을 통한 진통작용 (2) 해결하려는 과제기존 진통작용 약물의 부작용(3) 과제의 해결 수단대극과식물의 유효성분(4) 효과 등부작용 없는 효과적인 진통작용