BONFANTI, Jean-François,DOUBLET, Frédéric Marc Maurice,EMBRECHTS, Werner,FORTIN, Jérôme Michel Claude,MC GOWAN, David Craig,MULLER, Philippe,RABOISSON, Pierre Jean-Marie Bernard
申请号：
ES12784574
公开号：
ES2690082T3
申请日:
2012.11.08
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula (I) ** Formula ** or a pharmaceutically acceptable salt, a solvate or a polymorph thereof, wherein Y is (C 1-4) alkylene, R 1 is selected from the group consisting of imidazolyl, pyrazolyl, pyrrolyl , furyl, oxadiazolyl, oxazolyl and pyrimidyl, each of which is optionally substituted with one or more substituents independently selected from halogen, hydroxyl, C1-6 alkyl, C1-4 alkoxy or C3-6 cycloalkyl and R2 is an aryl2 or a heterocyclic； wherein the term aryl2 includes phenyl, naphthyl, anthracenyl and phenanthrenyl, and is optionally substituted with one or more substituents independently selected from hydroxyl, C1-6 alkyl, C1-4 alkoxy, trifluoromethyl, CO2R3, halogen, hydroxylalkyl (C1-4) , NR6R7, C (O) R6, C (O) NR6R7, alkyl (C1-4) -diethoxyphosphoryl or alkyl (C1-4) -phosphonic acid, wherein R3 is selected from H and C1-6 alkyl, and R6 and R7 is each independently selected from H, C1-6 alkyl and C1-4 alkoxy； and wherein the term heterocyclyl refers to a tetrahydropyran and heteroaryl2； the term heteroaryl2 includes pyridyl, tetrahydroisoquinolinyl, imidazopyridinyl, quinolinyl, isoquinolinyl, pyrazinyl, pyrimidyl, naphthyridinyl, pyridacinyl, benzimidazolyl, benzothiazolyl, pyrazolyl, thiazolyl, imidazolyl, indazolyl； the heteroaryl2 is optionally substituted with one or more substituents independently selected from halogen, hydroxyl, C1-6 alkyl, C1-4 alkoxy, oxy-(C1-4) alkyl-amino or pyrrolidinylmethanone.Un compuesto de fórmula (I)**Fórmula** o una sal farmacéuticamente aceptable, un solvato o un polimorfo del mismo, en donde Y es alquileno (C1-4), R1 se selecciona del grupo que consiste en imidazolilo, pirazolilo, pirrolilo, furilo, oxadiazolilo, oxazolilo y pirimidilo, cada uno de los cuales está opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente de halógeno, hidroxilo, alquilo C1-6, alcoxi C1-4 o cicloalquilo C3-6 y R2 es un arilo2 o un heterocicliclo； en donde el término arilo2 incluye fenilo, nafti
