Purdue Research Foundation;Coferon, Inc.;Cornell University
发明人:
Francis Barany,Maneesh Pingle,Donald E. Bergstrom,Sarah F. Giardina,Lee Daniel Arnold
申请号：
US15247539
公开号：
US20170080001A1
申请日:
2016.08.25
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Described herein are silyl monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. Such multimer forming associations of monomers may be promoted by the proximal binding of the monomers to their target biomolecule(s). In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.
