Lee Daniel Arnold,Kenneth W. Foreman,Douglas S. Werner
申请号：
US14193522
公开号：
US20140243286A1
申请日:
2014.02.28
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.
