PROCESS FOR {3- [2(R)- [(1R)-1- [3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY]-3(S)-(4-FLUOROPHENYL)MORPHOLIN-4-YL]METHYL]-5-OXO-4,5-DIHYDRO- [1,2,4]-TRIAZOL-1-YL}PHOSPHONIC ACID
MATTY, LOUIS,路易斯 玛帝,路易斯 瑪帝,MCNAMARA, JAMES MICHAEL,詹姆士 麦可 马克娜玛瑞,詹姆士 麥可 馬克娜瑪瑞,ROSEN, JONATHAN D.,强那森D 罗森,強那森D 羅森
申请号：
TW094138638
公开号：
TWI358413B
申请日:
2005.11.03
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
This Hair Ming Department Off Yu mono- Seed System Prepare compounds { 3- [2 (R)-[(1R) -1- [3,5- Twin (trifluoromethyl) phenyl] ethyoxyl] -3 (S)-(4- fluorophenyls) Do quinoline base -4- bases] methyl } -5- ketone groups -4, bis- Hydrogen [1 of 5-, 2,4]-triazol-1-yl } phosphonic acids Ji on Qi Medical Drug Ke Jie Shou Which Class method. This compound can effectively make As P Wu Quality (refreshing -1) Shou Body antidotes of The kassinin kinins (neurokinin). For spy it, The compounds can be effective, such as with what Zhi Treatment Vomit Tu Ji Hair inflammation diseases.本發明係關於一種製備化合物{3-[2(R)-[(1R)-1-[3,5-雙(三氟甲基)苯基]乙氧基]-3(S)-(4-氟苯基)嗎啉基-4-基]甲基}-5-酮基-4,5-二氫[1,2,4]-三唑-1-基}膦酸及其醫藥上可接受鹽類之方法。此化合物可有效的作為P物質(神經激肽(neurokinin)-1)受體拮抗劑。特而言之,該化合物可有效,例如用於治療嘔吐及發炎疾病。
