John A. Chiorini,Giovanni Di Pasquale,Edoardo Mannucci
申请号：
US14112790
公开号：
US20140199272A1
申请日:
2012.04.19
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to a gene transfer-based method to protect a subject from diabetes or obesity. The method comprises administering to a salivary gland of the subject an AAV virion comprising an AAV vector that encodes an exendin-4 protein. Also provided are exendin-4 proteins and nucleic acid molecules that encode such exendin-4 proteins. Also provided are AAV vectors and AAV virions that encode an exendin-4 protein. One embodiment is an exendin-4 protein that is a fusion protein comprising an NGF secretory segment joined to the amino terminus of an exendin-4 protein domain.
