AAV MEDIATED CTLA-4 GENE TRANSFER TO TREAT SJOGRENS SYNDROME

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专利权人:

John A. Chiorini

发明人:

John A. Chiorini,Hongen Yin

申请号：

US14111604

公开号：

US20140147418A1

申请日:

2012.04.13

申请国别(地区):

US

年份:

2014

代理人:

摘要：

The invention relates to a gene transfer-based method to protect a subject from Sjogrens syndrome. The method comprises administering to the subject an AAV virion comprising an AAV vector that encodes a soluble CTLA-4 (sCTLA-4) protein. Also provided are sCTLA-4 proteins and nucleic acid molecules that encode such sCTLA-4 proteins. Also provided are AAV vectors and AAV virions that encode a sCTLA-4 protein.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/