FEDERALNOE GOSUDARSTVENNOE BJUDZHETNOE UCHREZHDENIE "NAUCHNO-ISSLEDOVATELSKIJ INSTITUT KOMPLEKSNYKH PROBLEM SERDECHNO-SOSUDISTYKH ZABOLEVANIJ" SIBIRSKOGO OTDELENIJA ROSSIJSKOJ AKADEMII MEDITSINSKIKH N
发明人:
BARBARASH OLGA LEONIDOVNA,Барбараш Ольга Леонидовна,ZYKOV MIKHAIL VALEREVICH,Зыков Михаил Валерьевич,KULISH ELENA VLADIMIROVNA,Кулиш Елена Владимировна,GOLUBENKO MARIJA VLADIMIROVNA,Голубенко Мария Вл
申请号：
RU2012137373/14
公开号：
RU0002502474C1
申请日:
2012.08.31
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention relates to field of medicine, namely to cardiology. In order to perform genetic diagnostics of unfavourable outcome in patients within one year after acute coronary syndrome with ST segment elevation, analysis of polymorphic candidate genes of cardiovascular diseases and risk stratification on the basis of point estimation system are performed. Determined are: genotypes of polymorphic version of rs429I gene of angiotensin-converting enzyme (ACE), polymorphic version of rs6025 gene of V clotting factor (F5), as well as genotypes of polymorphic version of rs5918 gene of platelet glycoprotein IIIa (IGTB3). Identified genotype TT by polymorphism ts4291 (ACE gene) is assessed as 2 points, genotype AT is assessed as 1 point, genotype AA - as 0 points genotype TT by polymorphic rs6025 (F5 gene) - as 2 points, genotype CT - as 1 point, genotype CC - as 0 points genotype CC of polymorphism of rs5918 IGTB3 gene is given 2 points, genotype CT - 1 point, and genotype TT - 0 points. Minimal risk of development of unfavourable events is determined when the sum of points equals 0-1, medium risk when the sum of points equals 2, and high risk, when the sum of points equals 3-4.EFFECT: method makes it possible to predict development of unfavourable outcome in patients 12 months after acute coronary syndrome with segment ST elevation and perform risk stratification on the basis of point system of assessment by results of analysis of markers of candidate genes of cardiovascular diseases.3 tbl, 2 exИзобретение относится к области медицины, а именно к кардиологии. Для генетической диагностики неблагоприятных исходов у больных в течение одного года после острого коронарного синдрома с подъемом сегмента ST проводят анализ полиморфных генов-кандидатов сердечно-сосудистых заболеваний и стратификацию риска на основании бальной системы оценки. Определяют генотипы полиморфного варианта rs4291 гена ангиотензин-превращающего фермента (АСЕ), полиморфного вариан
