A herbicidal composition is provided, the composition comprising an herbicidally effective amount of mesotrione and at least one second herbicidal agent, wherein the second herbicidal agent comprises nicosulfuron and dicamba or salts thereof. There is also provided a method of controlling plant growth at a locus using the aforementioned composition. Further, a method of controlling growth of undesirable vegetation in crops, particularly maize (corn), comprises applying to the locus of the undesirable vegetation, an herbicidally effective amount of mesotrione and a second herbicidal agent, the second herbicidal agent comprising nicosulfuron and dicamba or salts thereof.