The technology relates to the use of a proteolytic enzyme, for example hyaluronidase, for the treatment of abnormal protein collection in a patients lymphatic system. In addition, the present technology provides a composition and a combined preparation each comprising hyaluronidase and at least one further proteolytic enzyme, and a method of prevention and/or treating primary or secondary edema in a patient in need thereof, wherein the patient is administered a therapeutically effective amount of hyaluronidase.
