13,13-dimethyl-des-C,D analogs of 1α,25-dihydroxy-19-nor-vitamin D3 compounds and topical composition dosage forms and methods of treating skin conditions thereof
Hector F. DeLuca;Margaret Clagett-Dame;Lori A. Plum;Rafal R. Sicinski;Katarzyna Plonska-Ocypa;Nirca J. Nieves;Pawel Grzywacz
发明人:
Hector F. DeLuca,Margaret Clagett-Dame,Lori A. Plum,Rafal R. Sicinski,Katarzyna Plonska-Ocypa,Nirca J. Nieves,Pawel Grzywacz
申请号：
US12357702
公开号：
US08193171B2
申请日:
2009.01.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
13,13-Dimethyl-des-C,D analogs of 1α,25-dihydroxy-19-nor-vitamin D3 compounds and topical composition dosage forms thereof, and methods of treating skin conditions thereof. Exemplary active pharmaceutical ingredients include (1R,3R)-5-[(E)-(S)-11′-hydroxy-5′,5′,7′,11′-tetramethyl-dodec-2′-enylidene]-2-methylene-cyclohexane-1,3-diol, (1R,3R)-5-[(Z)-(S)-11′-hydroxy-5′,5′,7′,11′-tetramethyl-dodec-2′-enylidene]-2-methylene-cyclohexane-1,3-diol, (1R,3R)-5-[(E)-(R)-11′-hydroxy-5′,5′,7′,11′-tetramethyl-dodec-2′-enylidene]-2-methylene-cyclohexane-1,3-diol, and (1R,3R)-5-[(Z)-(R)-11′-hydroxy-5′,5′,7′,11′-tetramethyl-dodec-2′-enylidene]-2-methylene-cyclohexane-1,3-diol.
