The invention refer to a nutraceutical supplement for honey bees, intended to increase their tolerance to biotic and abiotic stresses. Nutraceutic supplement is made up of 00.395-0.41 parts p-coumaric acid, 0.43-0.45 parts caffeic acid, 4.15-4.3 parts maltol, 4.25-4.3 parts fructo-oligosaccharides, with less than 10 residues of hexoses per molecule, 0.97-1 parts magnesium stearate, 33.9-35 parts sodium bicarbonate, 15.5-16 parts citric acid, 11.6-12 parts tartaric acid, 23.3-24 parts of dextrose-maltose mixture, spray-crystallized, up to 100 parts water.The administration process involves the dissolution of above composition, predosed, formulated as effervescent tablet, followed by dilution of the obtained solution with bees feed syrups, and applying of the diluted solutions, as needed, by spraying on the body of the hive, by spraying on the bee frames and honey bees, or as a stimulative nutraceutic supplement in the bees feed syrups.