Modified natural killer cells and natural killer cell lines having increased cytotoxicity

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专利权人:

Onkimmune Limited

发明人:

Michael O'Dwyer,Michael ODwyer

申请号：

US15405163

公开号：

US10034925B2

申请日:

2017.01.12

申请国别(地区):

US

年份:

2018

代理人:

摘要：

NK cells and NK cell lines are modified to increase cytotoxicity, wherein the cells and compositions thereof have a use in the treatment of cancer. Production of modified NK cells and NK cell lines is via genetic modification to remove checkpoint inhibitory receptor expression and/or add mutant (variant) TRAIL ligand expression.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/