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NON-NATURAL NKG2D RECEPTORS THAT DO NOT DIRECTLY SIGNAL THE CELLS TO WHICH THEY ARE ATTACHED
专利权人:
XYPHOS BIOSCIENCES INC.
发明人:
Kaman C. KIM,David W. MARTIN, JR.,Steven WILLIAMS
申请号:
US16674705
公开号:
US20200138866A1
申请日:
2019.11.05
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present disclosure relates to non-natural NKG2D receptors attached to mammalian cell surfaces wherein the non-natural receptors do not directly signal or directly activate the cell when the receptor is bound by cognate non-natural α1-α2 domains of NKG2D ligands modified to specifically bind the non-natural NKG2D receptors. The non-natural α1-α2 domains of NKG2D ligands may be attached to heterologous atoms or molecules including polypeptides, in some embodiments cytokines or modified cytokines, antibodies or fragments of antibodies.
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