GROSMAIRE LAURA SUE,GROSMAIRE Laura Sue,HAYDEN-LEDBETTER MARTHA SUSAN,HAYDEN-LEDBETTER Martha Susan,LEDBETTER JEFFREY A.,LEDBETTER Jeffrey A.,THOMPSON PETER ARMSTRONG,THOMPSON Peter Armstrong,SIMON SA
申请号：
SI200631765
公开号：
SI1912675T1
申请日:
2006.07.25
申请国别(地区):
SI
年份:
2014
代理人:
摘要：
The present disclosure generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the disclosure provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The application further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the disclosure provides humanized CD37-specific binding molecules.
