GROSMAIRE, LAURA SUE,HAYDEN-LEDBETTER, MARTHA SUSAN,LEDBETTER, JEFFREY A.,THOMPSON, PETER ARMSTRONG,SIMON, SANDY ALEXANDER,BRADY, WILLIAM
申请号：
DK10181126
公开号：
DK2298815T3
申请日:
2006.07.25
申请国别(地区):
DK
年份:
2015
代理人:
摘要：
The present disclosure generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the disclosure provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The application further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the disclosure provides humanized CD37-specific binding molecules.
