Mark J. Cantwell,Winnie M. Chan,Brett Ewald,Joan M. Robbins
申请号:
US15847612
公开号:
US20180169271A1
申请日:
2017.12.19
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Disclosed are replication-competent oncolytic adenoviruses, comprising chimeric human/mouse CD40 ligands. The oncolytic adenoviruses may be replication competent. The chimeric human/mouse CD40 ligand may be MEM40. Also disclosed are methods comprising administering a replication competent oncolytic adenovirus armed with at least one chimeric human/mouse CD40 ligand, for example MEM40, to a patient suffering from a cancer.