一種のオリゴヌクレオチド及びその応用
- 专利权人:
- 長春華普生物技術有限公司
- 发明人:
- 王 麗穎,胡 大利,孫 然,于 永利
- 申请号：
- JP2008202242
- 公开号：
- JP5415724B2
- 申请日:
- 2008.08.05
- 申请国别(地区):
- JP
- 年份:
- 2014
- 代理人:
- 摘要：
PROBLEM TO BE SOLVED: To provide an oligonucleotide inhibiting the stimulation to human peripheral blood monocyte proliferation by a Toll-like receptor 9 agonist, inhibiting the stimulation to the production of interferon by the human peripheral blood monocyte by the serum of a patient of Toll-like receptor 9 agonist, simple herpes virus type I, influenza virus and systemic lupus erythematosus, and rescuing an individual from cytokine-mediated lethal shock.
SOLUTION: The oligonucleotide has a kind of a nucleotide sequence of 5-cctcctcctcctcctcctcctcct-3. The oligonucleotide is used for the treatment of systemic lupus erythematosus, sepsis, multiple organ dysfunction syndromes and other immune-mediated disorders.
COPYRIGHT: (C)2010,JPO&INPIT
- 来源网站：
- 中国工程科技知识中心
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