A composition for transdermal permeation and a preparation method are disclosed. The composition including meloxicam as an active ingredient and further including at least one permeation enhancing agent selected from the group consisting of a sorbitan fatty acid derivative, a polyglyceryl fatty acid derivative, a polyethylene glycol vegetable oil ester, a polyethylene glycol corn oil glyceride, and a polyethylene glycol almond oil glyceride and at least one acrylic polymer adhesive having a hydroxyl group or no functional group.
