The present invention relates to methods for regulating the condition ofmammalian keratinous tissue wherein the methods each comprise the step oftopically applying to the keratinous tissue of a mammal needing suchtreatment, a safe and effective amount of a skin care composition comprising:a) a safe and effective amount of a hexamidine compound selected from thegroup consisting of hexamidine, its salts, and derivatives； b) a safe andeffective amount of one or more skin care active selected from the groupconsisting of sugar amine, vitamin B3, retinoid, peptide, phytosterol,butylated hydroxytoluene and butylated hydroxyanisole, their derivatives, andcombinations thereof； and c) a dermatologically acceptable carrier for thehexamidine and the skin care active. In additional embodiments, the abovecomposition is suitable for preventing, retarding, and/or treating dark under-eye circles, puffy eyes, sagging, sallowness as well as spider vessels and/orred blotchiness of skin, promoting skin desquamation, exfoliation, and/orturnover, regulating and/or reducing pore size appearance,preventing/retarding tanning, regulating oily/shiny appearance, preventing,retarding, and/or treating hyperpigmentation in mammalian skin, preventing,retarding, and/or treating itchiness of mammalian skin, preventing, retarding,and/or treating dryness of skin, preventing, retarding, and/or treating finelines and wrinkles, preventing, retarding, and/or treating skin atrophy ofmammalian skin, softening and/or smoothing lips, hair and nails of a mammal,and preventing, retarding, and/or treating the appearance of cellulite inmammalian skin.
