Multivalent immunogenic composition comprising 13 (capsular polysaccharide of different Serotype of Streptococcus pneumoniae Protein together with Acceptable vehicle and a method for Inducing an immune response to a polysaccharide conjugate.
HAUSDORFF WILLIAM P.,SIBER GEORGE RAINER,PARADISO PETER R.
申请号：
CL2016000566
公开号：
CL2016000566A1
申请日:
2016.03.10
申请国别(地区):
CL
年份:
2016
代理人:
摘要：
It describes a method for the production of multifunctional immune formulations, including 13 different polysaccharide protein mixtures, as well as selective aluminum adyvante. More specifically, the copolymers are realized by reducing ammonia, in which case, after the individual glucose copolymers are purified, these substances are combined to form immune components.Se describe un método para producir una formulación inmunogénica multivalente, que comprende 13 conjugados polisacarido-proteina diferenciados y, optativamente, un adyuvante a base de aluminio. Más específicamente, la conjugación es realizada a través de aminación reductora y donde luego de que los gluco-conjugados individuales son purificados estos son combinados para formular la composición inmunogénica.
