2-ARYL-3,5-DICYANO-4-INDAZOLYL-6-METHYL-1,4-DIHYDROPYRIDINES FLUORO-SUBSTITUEES ET LEURS UTILISATIONS

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专利权人:

BAYER PHARMA AKTIENGESELLSCHAFT

发明人:

VAKALOPOULOS, ALEXANDROS,MICHELS, MARTIN,ZIMMERMANN, KATJA,TEUSCH, NICOLE,LOBELL, MARIO,ENGEL, KAREN

申请号：

CA2777907

公开号：

CA2777907C

申请日:

2010.11.08

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present invention relates to novel,fluoro-substituted 2-aryl-3,5-dicyano-4-(1H-indazol-5-yl)-6-methyl-1,4-dihydropyridine derivatives(see formula I)wherein Ar and R1-R4 are as defined in the specification, having proteintyrosine kinase inhibitoryactivity, to a process for the manufacture thereof and to the use thereof forthe treatment ofc-Met-mediated diseases or c-Met-mediated conditions, particularly Cancer andother proliferative disorders.

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