A plurality of heterocyclic fused anthraquinone derivatives are disclosed in the present invention. The heterocyclic fused anthraquinone derivatives is represented by a formula (I): wherein R1 is a substituent being one selected from a group consisting of hydrogen, halogens, alkylamino group, alkylthio group, haloalkyl group, piperazino group, sulfonyl group, morpholino group, alkali group or one substituent represented by a formula (II): wherein R2 is amino group, oxyl group or a thiol group. In the meantime, a method for manufacturing the above-mentioned heterocyclic fused anthraquinone derivatives and a pharmaceutical composition using thereof are also disclosed here.本發明提供一種雜環融合蒽醌衍生物,用以抑制非核苷類端粒酶,其係由式I所示:式I中,R1代表氫原子、鹵系元素、烷基胺基、烷基硫基、鹵烷基、哌嗪基、磺酸基、嗎啉基、金屬鹽或由式II所示之取代基:式II中,R2代表胺基、氧基或硫基,且式II中苯基的氫元素可部分地由鹵系元素、烷氧基、硝基、甲硫基或巰基取代。同時,本發明亦揭露一種製備上述雜環融合蒽醌衍生物的方法及包含其之醫藥組合物。
