The present invention relates a preparation method of pharmaceutical composition comprising pyrrolo six-member heterocyclic compound or its medicinal salt thereof. In particular, the present invention relates a preparation method of pharmaceutical composition comprising the step of mixing 5-(2-Diethylamino-ethyl)-2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-lylidenemethyl-methyl)-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one or its pharmacologically acceptable salt and at least one water-soluble filler and then granulating. The composition has the characteristics of rapid dissolution and good stability.本發明提供了一種含有吡咯并六員雜環化合物或其可藥用鹽的藥物組成物的製備方法。具體而言,本發明提供了一種藥物組成物的製備方法,包括將5-(2-二乙胺基-乙基)-2-(5-氟-2-酮基-1,2-二氫-吲哚-3-亞基-甲基)-3-甲基-1,5,6,7-四氫-吡咯[3,2-c]吡啶-4-酮或其藥理學上可接受的鹽與至少一種填充劑混合後進行製粒的步驟。本發明的藥物組成物具有溶出迅速、穩定性良好的特點。本案的圖為實驗數據,並非本案的代表圖。故本案無指定代表圖。
