PROBLEM TO BE SOLVED: To provide a method of inhibiting abnormal increase of histone O-GlcNAc modification evoked by hyperglycemia and a composition therefor.SOLUTION: The present invention provides a composition comprising a compound represented by the following formula (I), or salt thereof as an active ingredient.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】高血糖が惹起するヒストンO-GlcNAc修飾の異常増加の抑制方法及びそのための組成物の提供。【解決手段】下記式(I)で表される化合物、又はその塩を有効成分として含有する組成物。【選択図】なし