GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
WHANG, GUI SEO,황귀서,KIM, BOK DEUK,김복득,NAM, YOON JEONG,남윤정,PARK, JEONG HILL,박정일,PARK, KUN KOO,박건구
申请号：
KR1020110087704
公开号：
KR1020130024325A
申请日:
2011.08.31
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: An external use skin pharmaceutical composition and a cosmetic composition containing brazilin or a pharmaceutically acceptable salt thereof are provided to control factors related to collagen generation and decomposition.CONSTITUTION: An external use skin pharmaceutical composition for preventing and treating wrinkles contains brazilin or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition is a cream, a gel, a patch, a spray, an ointment, a liniment, a lotion, a pasta, or cataplasma. A cosmetic composition for preventing and treating wrinkles contains brazilin or a pharmaceutically acceptable salt thereof as an active ingredient. The cosmetic composition is manufactured in the form of a lotion, a skin, a nutrition lotion, a nutrition cream, a massage cream, an essence, or a pack.COPYRIGHT KIPO 2013본 발명은 Brazilin은 UV의해 증가된 LDH의 유리, 니트라이트, MMP-1, c-fos, c-jun, iNOS 의 유전자 발현을 감소, UV에 의해 생성이 감소한 TIMP-1, 프로콜라겐, Bcl-2 유전자 발현을 증가시켜 콜라겐의 생성 및 분해에 관련된 인자들을 조절하여 주름살 억제 및 UV 유발 피부손상 억제를 확인함으로써 피부 주름의 치료 및 예방에 유용한 조성물을 제공할 수 있다.
