KIM, BOK DEUK,김복득,WHANG, GUI SEO,황귀서,YOON, TAE WON,윤태원,LEE, JIN KYUN,이진균,YOO, DONG YOUL,유동렬
申请号：
KR1020110087824
公开号：
KR1020130024395A
申请日:
2011.08.31
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A pharmaceutical composition and a cosmetic composition containing brazilin or a pharmaceutically acceptable salt thereof are provided to suppress the expression of genes such as COX-2, iNOS, TNF-alpha, c-fos, and c-jun, and to prevent and treat skin aging.CONSTITUTION: A pharmaceutical composition for preventing and treating skin aging contains brazilin or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition is manufactured in the form of a cream, a gel, a patch, an ointment, a liniment, a pasta, or a cataplasma. A cosmetic composition for preventing and treating skin aging contains brazilin or a pharmaceutically acceptable salt thereof. The cosmetic composition is manufactured in the form of a lotion, a skin, a nutrition lotion, a nutrition cream, a massage cream, an essence, or a pack.COPYRIGHT KIPO 2013본 발명의 브라질린(Brazilin)은 UV로 자극된 HaCaT의 상해로 인한 생존능을 증가시키고, apoptosis를 억제하는 Bcl-2, Bax 등의 유전자 발현을 증가시켰다. 이와 함께, UV에 의해서 증가된 COX-2, iNOS, TNF-α, c-fos, c-jun의 유전자 발현을 억제하여 노화 억제 및 UV 유발 피부손상 억제를 확인함으로써 피부 노화의 치료 및 예방에 유용한 조성물을 제공할 수 있다.
