BARTKOVITZ DAVID JOSEPH,VU BINH THANH,ZHAO CHUNLIN,FISHLOCK DANIEL,CHU XIN-JIE
申请号：
NZ62650513
公开号：
NZ626505A
申请日:
2013.03.12
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
The disclosure relates to substituted pyrrolidine-2-carboxamides of formula (I) for the treatment of cancer. Example compounds include: 3-Oxo-2,4,7,10,13,16,19-heptaoxaixosyl 4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoate 4-{ [(2R,3S,4R,5S)-3-(3-Chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino} -3-methoxy-benzoic acid 1-mPEGcarbonyloxy-ethyl ester (mPEG, average MW ~2000). 4-{ [(2R,3S,4R,5S)-3-(3-Chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino} -3-methoxy-benzoic acid 1-rnPEGcarbonyloxy-ethyl ester (rnPEG, average MW ~2200) 4-{ [(2R,3S,4R,5S)-3-(3-Chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl] -amino} -3-methoxy-benzoic acid 1-mPEGcarbonyloxy-methyl ester (rnPEG, average MW ~2000)
