BARTKOVITZ DAVID JOSEPH,VU BINH THANH,ZHAO CHUNLIN,CHU XIN-JIE,EHRLICH GEORGE,LIU JIN-JUN,MICHEL HANSPETER
申请号：
NZ63147713
公开号：
NZ631477A
申请日:
2013.05.27
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
The disclosure relates to pyrrolidine-2-carboxamido compounds of the formula (I), enantiomers and pharmaceutically acceptable salts and esters thereof, wherein the variables X, Y, Z, R1, R2 and R3 are as described herein. Also disclosed are methods of making these compounds, as well as the use of such compounds as medicaments, especially as anticancer agents. Exemplary salt of the pyrrolidine-2-carboxamido compound is 2-(Phosphonooxy)ethyl 4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoate, trifluoroacetate salt.
