Bernard T. Golding;Robert G. Tyson;Richard Franklin;Martin Quibell
发明人:
Richard Franklin,Martin Quibell,Robert G. Tyson,Bernard T. Golding
申请号：
US13253677
公开号：
US20120202756A1
申请日:
2011.10.05
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to prodrugs of a wide variety of drugs and pharmaceutical compositions containing such prodrugs. Methods for minimizing locally mediated (from within the gut lumen) adverse gastrointestinal events associated with the underivatised drug and increasing the sustainment of plasma drug levels with the aforementioned prodrugs are also provided. Thus, the present invention relates to the use of prodrugs of a wide diversity of drugs (other than opioids) to transiently inactivate them and so reduce directly, locally mediated adverse gastrointestinal (GI) side-effects normally evident after administration of the parent compound. Additionally, such prodrugs may confer improved pharmacokinetics.
