A system and method for monitoring disease, such as lung disease via a communication device of a user is disclosed. The system and method may include a communication device, such as a smartphone, a laptop, a smartwatch and the like, and may including a memory and a processor configured to: obtain information related to a user's medical condition; determine, while the user is using the communication device, respiratory characteristics of the user based on a recording of a respiration of the user; and determine a progress of a disease of the user based on the user's medical condition and based on comparing the characteristics to a reference set of characteristics. The reference set of characteristics may be created, by the processor, by obtaining signals related to the user's breathing while the user uses the communication device.