A system and method for monitoring and determining a medical condition of a user, via a communication device of the user is disclosed. The system and a method according to some embodiments, may comprise a memory and a processor, the processor may be configured to receive an audio signal related to a user's speech, and determine a progress of a disease of the user based on comparing the audio signal to a reference audio signal. According to some embodiments, the memory and processor may be included in a mobile communication device operated by the user, the reference audio signal may be generated based on recording normal speech of the user e.g. during telephone calls.
