RAJOPADHYE, MILIND,HO, GUOJIE,BEDNAR, BOHUMIL,DUONG, LE T.,COLEMAN, PAUL J.
申请号：
CA2715034
公开号：
CA2715034C
申请日:
2009.03.13
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention provides a family of agents that target integrins, which can beused as imaging agents and/or therapeutic agents. The agents comprise (a) anintegrintargeting moiety (ITM) comprising an alkyl substituted tetrahydro-1,8-naphthyridine moiety,wherein the alkyl is substituted with an aryl or heteroaryl moiety； and (b) areporterchemically linked, optionally through a linker (L) moiety, to the integrintargeting moiety.The agents can be used to image angiogenesis, inflammation or otherphysiological processesin a subject.
