Richard L. Guerrant;Michael P. Timko;Glynis L. Kolling;Cirle Alcantara Warren;Evelyn Durmaz;Todd R. Klaenhammer
发明人:
Todd R. Klaenhammer,Richard L. Guerrant,Glynis L. Kolling,Evelyn Durmaz,Michael P. Timko,Cirle Alcantara Warren
申请号：
US13697860
公开号：
US09040302B2
申请日:
2011.05.19
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Methods and compositions for targeted delivery of biotherapeutics are provided. The compositions comprise bile-sensitive St. thermophilus bacteria modified to release a biotherapeutic agent following bile exposure. Biotherapeutic agents released by the St. thermophilus bacteria disclosed herein include AQ and AQR rich peptides. Methods of the invention comprise administering to a subject a St. thermophilus bacterium modified to release a biotherapeutic agent following bile exposure. Administration of the St. thermophilus bacterium promotes a desired therapeutic response. The bacterium may be modified to express and release AQ or AQR rich peptides which subsequently inhibit cellular apoptosis or reduce mucosal damage. Thus, methods of the invention find use in treating or preventing a variety of gastrointestinal disorders including C. difficile infection and antibiotic-associated diarrhea.
