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Inoculation of recombinant viral vectors for rapid pre-exposure prevention and post-exposure protection against alpha-virus-induced encephalitides
专利权人:
Josh Qiaohua Wu
发明人:
Josh Qiaohua Wu,Leslie P. Nagata
申请号:
US12545933
公开号:
US08303947B2
申请日:
2009.08.24
申请国别(地区):
US
年份:
2012
代理人:
摘要:
This invention addresses how to rapidly prevent alphavirus-induced encephalitides before and after exposure to alphaviruses. The invention discloses a single dose administration of two types of recombinant viral vectors: one expressing interferon and another expressing the structural proteins of alphaviruses or a single dose administration of the recombinant viral vector co-expressing both interferon and the structural proteins of alphaviruses. This invention can be used to prevent humans from alphavirus-induced encephalitides in the event of a bioterrorism attack or biowarfare in which alphaviruses such as Venezuelan (VEEV), eastern (EEEV) and western (WEEV) equine encephalitis viruses are deliberately released to humans, a natural outbreak of alphaviruses, and an accidental exposure to alphaviruses in laboratory.
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