Target gene and a target protein of a physiologically active substance such as a drug, and a means capable of developing a new physiologically active substance using these. Specifically, the target gene and the target protein of a physiologically active substance The complex comprising a target protein with a physiologically active substance method of producing physiologically active substance derivative modulator of physiological activity screening method for a substance capable of regulating the physiological activity kits containing physiologically active substance or a salt thereof and method for determining risk or onset of a disease or condition in a predetermined method of determining sensitivity to physiologically active substance, and is used in the determination method the method of manufacturing a composite body, and I provide such determination kit is.薬物等の生理活性物質の標的タンパク質及び標的遺伝子、およびこれらを用いる新規生理活性物質を開発し得る手段を提供する。具体的には、生理活性物質の標的タンパク質および標的遺伝子;生理活性を調節し得る物質のスクリーニング方法;生理活性の調節剤;生理活性物質誘導体の製造方法;生理活性物質と標的タンパク質とを含む複合体、および当該複合体の製造方法;並びに生理活性物質またはその塩を含むキット;所定の疾患または状態の発症または発症リスクの判定方法、生理活性物質に対する感受性の判定方法、および当該判定方法に用いられる判定用キットなどを提供する。
