An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase

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专利权人:

Genzyme Corporation

发明人:

Liu, Hanlan,Willis, Chris,Bhardwaj, Renu,Copeland, Diane P.,Harianawala, Abizer,Skell, Jeffrey,Marshall, John,Kochling, Jianmei,Palace, Gerard,Peterschmitt, Judith,Siegel, Craig,Cheng, Seng

申请号：

AU2016202591

公开号：

AU2016202591A1

申请日:

2016.04.22

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

#$%^&*AU2016202591A120160519.pdf#####H:Vc Intrwovn NRPortbl DCC REC l0029214_I.docx-21/04/2016 ABSTRACT The hemitartrate salt of a compound represented by the following structural formula: N O H 0 N H (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.

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