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THE USE OF SUCCINATE DERIVATIVE ESTERS FOR THE TREATMENT OF DEMENTIA
专利权人:
发明人:
申请号:
EP03782083.4
公开号:
EP1582209B1
申请日:
2003.12.31
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The use of extract from Wangla (coeloglossum viride (L) Hartm. Var. Bracteatum (willd.) Richter), succinate derivative esters, and a derivative and pharmaceutical acceptable salts thereof, for the manufacture of a pharmaceutical preparation for the treatment of dementia, particularly for the treatment of Alzheimer disease and Vascular dementia. Through animal experiment, it has been demonstrated that, succinate derivative esters can improve learning and memory ability in dementia rats induced by scopolamine and cyclohexenyl imine improve learning and memory ability in dementia rats induced by β -amyloid improve learning and memory ability in dementia rats induced by permanent ligation of bilateral carotid and improve memory ability of normal animals. It has the advantage of high activity, low toxicity and no inhibition to cholinesterase.
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