ABRAHAM, SUNNY,BHAGWAT, SHRIPAD,CAMPBELL, BRIAN T.,CHAO, QI,FARAONI, RAFFAELLA,HOLLADAY, MARK W.,LAI, ANDILIY G.,ROWBOTTOM, MARTIN W.,SETTI, EDUARDO,SPRANKLE, KELLY G.
申请号：
CA2718123
公开号：
CA2718123C
申请日:
2009.03.17
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Compounds according to formula (I), compositions and methods are provided formodulating the activity of RAFkinases, including BRAF kinase and for the treatment, prevention, oramelioration of one or more symptoms of disease or disordermediated by RAF kinases. Formula (I): or a pharmaceutically acceptable salt,solvate, clathrate of hydrate thereof, wherein X is Oor S(O)t； Ra is O or S.
