A device for removing noxae from blood, in an extracorporeal perfusion system, includes a housing and a plurality of hollow fibers provided inside the housing, which can be perfused by the blood. The hollow fibers each have a plurality of pores that permit the plasma of the blood to flow through the pores from an inside of the hollow fibers to an outside of the hollow fibers. The hollow fibers are modified or pretreated, in particular chemically, in such a way that they have a functionalized surface which binds the noxae to itself and removes the noxae from the blood. An inside surface of the hollow fibers includes a coating, in particular a hemocompatible and anticoagulant coating, which is arranged to prevent damage to the cellular components of the blood when the blood flows through the hollow fibers. An extracorporeal perfusion system includes the device.
