A connection assembly for coupling an auxiliary drive system to a wheelchair for disabled people, of the type comprising a fixing structure adapted to be fixed to the framework of the wheelchair and a longitudinal member operatively connected to the fixing structure so that the longitudinal development axis of the longitudinal member is substantially parallel to the advancement direction of the wheelchair. The connection assembly comprises connection means associated with the free end of the longitudinal member and with the auxiliary drive system, such connection means are configured to allow rapid coupling and decoupling of the auxiliary drive system to/from the wheelchair.
