PURPOSE: A method for preparing an extended-release solid formulation of an insoluble drug is provided to ensure simple preparation and to improve safety and elution rate.CONSTITUTION: A method for preparing an extended-release solid formulation of an insoluble drug comprises: a step of heating cetyl alcohol in a sustained release formulation and phase-changing from semi-solid phase into a liquid phase a step of dissolving loxoprofen in the liquid phase cetyl alcohol and preparing a solution a step of adding a swelling polymer, a disintegrant, and an excipient in the solution and preparing a mixture a step of binder to the mixture and granulating by wet-granulation a step of drying the granules and mixing with a lubricant and a step of preparing a tablet or coated tablet.COPYRIGHT KIPO 2013본 발명은 유화제로 사용되는 고급지방 알코올류에 수 난용성인 로소프로펜을 가용화하여 용출율을 향상시킴과 동시에 수팽윤성 셀룰로오스 중합체와 함께 지속적인 방출제어를 할 수 있는 서방성제제를 통상적인 경구형 제제를 제조하는데 있다.
