PROBLEM TO BE SOLVED: To provide a novel low-molecular compound which suppresses production of amyloid beta (Aβ).SOLUTION: A compound represented by formula [I] or a pharmacologically allowable salt or ester thereof is effective as a therapeutic agent of a disease such as Alzheimer, wherein R1 and R2, which may be the same or different, each represent a substituent selected from the following substituent group a1 m represents an integer of 0-3 n represents an integer of 0-2 X1 represents a single bond or the like X2 represents a single bond or the like a ring A represents a 5-membered aromatic heterocyclic group which includes two or more nitrogen atoms and may have 1-3 substituents selected from the following substituent group b1 a ring B represents an aromatic cyclic group of single ring or condensed ring which may have 1-3 substituents selected from the following substituent group c1. Substituent group a1 C1-6 alkyl or the like, substituent group b1: C1-6 alkyl or the like, and substituent group c1: amino or the like.COPYRIGHT: (C)2012,JPO&INPIT【課題】アミロイドベータ(Aβ)の産生を抑制する新規な低分子化合物の提供。【解決手段】式[I][式中、R1及びR2は、それぞれ同一又は異なって、下記置換基群a1より選択される置換基を示し、mは、0-3の整数を示し、nは0-2の整数を示し、X1は、単結合などを示し、X2は、単結合などを示し、環Aは、窒素原子を2個以上含み、下記置換基群b1より選択される1-3個の置換基を有してもよい5員の芳香族複素環基などを示し、環Bは、下記置換基群c1より選択される1-3個の置換基を有してもよい単環又は、縮合環の芳香族環基を示す]で表される化合物又はその薬理学的に許容される塩若しくはエステルは、アルツハイマー病などの疾患の治療剤として有効である。置換基群a1:C1-6アルキル基など置換基群b1:C1-6アルキル基など置換基群c1:アミノ基など【選択図】なし
