Zwiazek pirymidynowy lub jego sól, kompozycja farmaceutyczna, zawierajace taki zwiazek, jej zastosowanie jako srodka do leczenia lub zapobiegania chorobom oraz zastosowanie zwiazku do wytwarzania srodka

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专利权人:

LTD.;EISAI R & D MANAGEMENT; CO.;EISAI R & D MANAGEMENT, CO., LTD.

发明人:

HARADA HITOSHI,HITOSHI HARADA,ASANO OSAMU,OSAMU ASANO,UEDA MASATO,MASATO UEDA,MIYAZAWA SHUHEI,SHUHEI MIYAZAWA,KOTAKE YOSHIHIKO,YOSHIHIKO KOTAKE,KABASAWA YASUHIRO,YASUHIRO KABASAWA,YASUDA MASAHIRO,MASA,MASAHIRO YASUDA,YASU

申请号：

PL370274

公开号：

PL215572B1

申请日:

2002.10.22

申请国别(地区):

PL

年份:

2013

代理人:

摘要：

The present invention provides a novel pyrimidine compound having an excellent adenosine receptor (A1, A2A, A2B receptor) antagonistic action. More specifically, it provides a compound represented by the following formula, a salt thereof or a solvate of them. <；CHEM>； <；??>；In the formula, R<；1>； and R<；2>； are the same as or different from each other and each represents a hydrogen atom, an alkyl group having one to six carbon atoms which may be substituted, an alkenyl group having two to six carbon atoms which may be substituted, an alkynyl group having two to six carbon atoms which may be substituted, a cycloalkyl group having three to eight carbon atoms which may be substituted, a cycloalkenyl group having three to eight carbon atoms which may be substituted, a 5 to 14-membered non-aromatic heterocyclic group which may be substituted, an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted, an acyl group having one to six carbon atoms which may be substituted or an alkylsulfonyl group having one to six carbon atoms which may be substituted； R<；3>； represents a hydrogen atom, a halogen atom, a cyano group, an alkyl group having one to six carbon atoms which may be substituted, an alkenyl group having two to six carbon atoms which may be substituted, an alkynyl group having two to six carbon atoms which may be substituted, an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted, a nitrogen atom which may be substituted, an oxygen atom which may be substituted or a sulfur atom which may be substituted； R<；4>； represents an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted or a 5 to 14-membered non-aro

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